team

Jayaraj Joseph

Assistant Professor

044-2257 4477

jayaraj@ee.iitm.ac.in

  • I am with the Measurements & Instrumentation Group in the EE Dept. of IIT Madras. I have more than 8 years experience in medical device development as Chief Technologist of Healthcare Technology Innovation Centre, IIT Madras.
  • I focus on development of novel sensing systems and instruments for non-invasive and non-contact assessment of the human physiology, and have a special interest in vascular health. I strive towards developing innovative sensing technology and solutions, that not only work in our laboratory, but operate reliably in a clinical setting for enabling large scale validation studies that are necessary to drive clinical adoption of our research.
  • I apply system design and product development concepts in my research to ensure that our research prototypes are reliable and usable in real-world clinical settings. In addition to engineering research and technology development in the lab, I perform pre-clinical validation using physiological phantoms, ex-vivo studies using excised tissues and in-vitro studies in small and large animals in collaboration with animal study partners, to ensure that the technologies that we develop are safe and reliable. I perform clinical validation of our technologies in collaboration with multiples hospitals in India and abroad.
  • I primarily work on novel sensing technologies, intelligent signal processing and automated measurement algorithms, and system design for medical devices. I also have a keen interest in renewable energy and am starting research in instrumentation for battery recycling plants.

  • Affordable, Accessible and Scalable technologies for creating large impact.
  • Devices for early screening, diagnosis and chronic disease management.
  • Vascular ageing assessment.
  • Cuff less blood pressure measurement.
  • Non contact physiological sensing.
  • Wearable sensors for health monitoring.
  • Point of care diagnostics.
  • ARTSENS : Image-free ultrasound for vascular ageing assessment.
  • Magnetic Plethysmo Graph (MPG) .
  • Accelerometer Plethysmo Graph (APG).
  • Portable fluorescent imaging modules for quantitative immunoassay testing.
  • Immunoassay based rapid testing devices and instrumentation.
  • Instrumentation for digital histology and computational neuroanatomy of human brain.
  • Renewable energy from ocean waves.
  • Oscillating Water Column based wave power modules.
  • Battery recycling & Urban Mining

  • Best paper award at the 2018 Russian German Conference in Aachen Germany, for the paper titled Variation in local Pulse Wave Velocity over a cardiac cycle: In-vivo validation using dual MPG arterial compliance probe.
  • Best paper award 2016 IEEE Symposium on Medical Measurements and Applications for paper titled ARTSENS Pen: A portable, image-free device for automated evaluation of vascular stiffness.
  • Winner of the 2015 National Instruments Engineering Impact Awards under 3 categories, viz (a) Customer Application of the Year (b) Advanced Research, and (c)Humanitarian Award for developing ARTSENS - An easy to use image-free technology for arterial stiffness evaluation and vascular screening.
  • Dr Mukunda Rao Endowment for the best PhD thesis in electrical engineering in inter-disciplinary areas of research by IIT Madras in 2011.
  • ENERTIA Award (Citation + Rs 1 lakh) 2010 for Idea Innovation in Institution for Wave Energy.
  • Silver Medal for highest CGPA in the first two semesters of M Tech ( IIT Madras ).
  • All India Rank 15 in GATE 2006; University of Kerala Rank 1 in B Tech.
  • Kerala State Rank 1 in Higher Secondary; Kerala State Rank 14 in Class X.

    Current Courses

  • EE1100 : Basic Electrical Engineering (April-June 2021; March - May 2022; March - June 2023)

    Previous Courses

  • EE5401 : Measurements and Instrumentation (July-Nov 2020)

Journals

  • S Natarajan and J Joseph, Signal enhancement using the europium nanoparticle over the organic dye in the quantitative lateral flow immunoassay development for the detection of the cTroponin I, Science Talks, vol 5, p 100151, Mar 2023.
  • K M van der Sluijs et al, Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls, American Journal of Physiology-Heart and Circulatory Physiology, vol 324, no 1, pp H47 H56, Jan 2023.
  • S Lyra et al, Camera fusion for real-time temperature monitoring of neonates using deep learning, Med Biol Eng Comput, vol 60, no 6, pp 1787 - 1800.
  • R Manoj, K V Raj, P M Nabeel, M Sivaprakasam, and J Joseph, Arterial pressure pulse wave separation analysis using a multi-Gaussian decomposition model, Physiol Meas, vol 43, no 5, May 2022.
  • P M Nabeel, K V Raj, and J Joseph, Image-free ultrasound for local and regional vascular stiffness assessment: the ARTSENS Plus, Journal of Hypertension.
  • S Natarajan, E Saati, and J Joseph, Development and Evaluation of Europium-Based Quantitative Lateral Flow Immunoassay for the Chronic Kidney Disease Marker Cystatin-C, J Fluoresc, vol 32, no 2, pp 419-426, Mar 2022.
  • K V Raj, P M Nabeel, and J Joseph, Image-Free Fast Ultrasound for Measurement of Local Pulse Wave Velocity: In Vitro Validation and In Vivo Feasibility, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol 69, no 7, pp 2248-2256, Jul 2022.
  • K V Raj, P M Nabeel, D Chandran, M Sivaprakasam, and J Joseph, High-frame-rate A-mode ultrasound for calibration-free cuffless carotid pressure: feasibility study using lower body negative pressure intervention, Blood Pressure, pp 1-12, Jan 2022.
  • S Natarajan and J Joseph, A novel time-resolved fluorescent lateral flow immunoassay for quantitative detection of the trauma brain injury biomarker-glial fibrillary acidic protein, Sensors & Diagnostics, 2022.
  • D Dayanand, Irudhayanathan I, Kundu D, Manesh A, Abraham V, Abhilash KP, Chacko B, Moorthy M, Samuel P, Peerawaranun P, Mukaka M, Joseph J, Sivaprakasam M and Varghese GM, Community seroprevalence and risk factors for SARS CoV-2 infection in different subpopulations in Vellore, India and its implications for future prevention, Int J Infect Dis, pp S1201-9712(21)01255-8, Dec 2021.

Conference Proceedings

  • R K V, R Manoj, I S, N P, and J Joseph, Operator Variabilities in Carotid Pulse Wave Velocity Measured by an Image-free Ultrasound Device, in 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Jul 2022, pp 4018-4021.
  • R K V, R Manoj, I S, N P M, and J Joseph, Comparison of Approximated and Actual Bramwell-Hill Equation Implementation for Local Pulse Wave Velocity: Ex-vivo Study, in 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Jul 2022, pp 3989-3992.
  • N Sudarsan, R Manoj, N P M, M Sivaprakasam, and J Joseph, Association of Windkessel Model Parameters with Local and Regional Aortic Stiffness Indices, in 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA), Jun 2022, pp 1-6.
  • N Sudarsan, R Manoj, N P M, M Sivaprakasam, and J Joseph, Association of Local Arterial Stiffness and Windkessel Model Parameters with Ageing in Normotensives and Hypertensives, in 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Jul 2022, pp 3997-4000.
  • N N Sahoo et al, Deep learning based non-contact physiological monitoring in Neonatal Intensive Care Unit, in 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Jul 2022, pp 1327-1330.
  • I S, R Manoj, R K V, N PM, and J Joseph, Hydrostatic Pressure Compensator for Evaluation of Carotid Stiffness using A-Mode Ultrasound: Design, Characterization, and In-Vivo Validation, in 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA), Jun 2022, pp 1-6.
  • R Manoj, V Raj Kiran, P Nabeel, M Sivaprakasam, and J Joseph, Evaluation of Pulse Contour Markers using an A-Mode Ultrasound: Association with Carotid Stiffness Markers and Ageing, in 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Jul 2022, pp 4010-4013.
  • R Manoj, V Raj Kiran, P M Nabeel, M Sivaprakasam, and J Joseph, Estimation of Characteristic Impedance using Multi-Gaussian Modelled Flow Velocity Waveform: A Virtual Subjects Study, in 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Jul 2022, pp 2274-2277.
  • R Manoj, V R Kiran, P Nabeel, M Sivaprakasam, and J Joseph, Assessment of Arterial Reflection Markers using an A-Mode Ultrasound Device, in 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA), Jun 2022, pp 1-6.
  • R Manoj, V R Kiran, P M Nabeel, M Sivaprakasam, and J Joseph, Variation in Pulse Contour Markers on an Anesthetized Porcine During Pressure Perturbation: Association with Local and Regional Stiffness, in 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA), Jun 2022, pp 1-6.
  • N R George, R K V, N PM, M Sivaprakasam, and J Joseph, Jugular Venous Diameter Measurement Using A-Mode Ultrasound: A Feasibility Study, in 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA), Jun 2022, pp 1-6.

Patents

  • J Joseph, V Jayashankar and B George, A magnetic transducer system for non-invasive detection of blood flow pulse and evaluation of arterial compliance, Indian Patent 381839, Nov 15, 2021.
  • J Joseph, M Sivaprakasam, and P M Nabeel, System for cuff-less blood pressure (BP) measurement of a subject, European Patent EP3157416B1, Jul 15, 2020.
  • J Joseph, M Sivaprakasam, and P M Nabeel, Method and system for cuff-less blood pressure (BP) measurement of a subject, United States Patent US10709424B2, Jul 14, 2020.
  • J Joseph, S Seshadri, J Venkataraman, M Sivaprakasam, and A Kumar Sahani, Automated evaluation of arterial stiffness for a non-invasive screening, Indian Patent 345719, Aug 24, 2020.
  • Lalit Mahajan, N Mahajan, J Joseph, J K Vasan, M Sivaprakasam A fluorescence analyser system for rapid lateral flow assays, Indian Patent No 332279, granted 18/02/2020.

Books Authored

  • "The technical journey of the Indian wave energy plant", edited by V Jayashankar, published by National Institute of Ocean Technology (Co-author of 3 chapters)

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