21st Century Endowed Chair in Nano-, and Bio-Technology and Medicine
Distinguished Professor of Electrical Engineering
Distinguished Professor of Biomedical Engineering
Director, NSF Wireless Nanosensors and Systems (WiNS)
Professor of Neurosurgery, College of Medicine
University of Arkansas, Fayetteville, AR 72701
Professor of Neurosurgery
Penn State Hershey Medical Center
Pennsylvania State University, Hershey, PA
Abstract: Nanotechnology has been broadly defined as the one for not only the creation of functional materials and devices as well as systems through control of matter at the scale of 1-100 nm, but also the exploitation of novel properties and phenomena at the same scale. Growing needs in the point-of-care (POC) that is an increasing market for improving patient’s quality of life, are driving the development of nanotechnologies for diagnosis and treatment of various life threatening diseases. This paper talk will address the recent development of nanodiagnostic sensors and nanotherapeutic devices with functionalized nanosensors on a flexible polymer based thin film electronics to monitor and control of two leading diseases namely 1) neurodegenerative diseases, 2) cardiovascular diseases. The sensors developed include implantable and biocompatible devices, light weight wearable devices in wrist-watches, hats, shoes, bra, bro, band-aid, bed sheets, pillow cases and other smart clothing. Many of these sensors are integrated with the wireless systems for the remote physiological monitoring. The author’s research team has also developed a wireless neural probe using nanowires, nanotubes and magnetic nanotubes for monitoring and control of Parkinson’s and Alzheimer’s diseases. They have demonstrated that magnetic nanotubes combined with nerve growth factor enable specific cells to differentiate into neurons. The results from in vitro studies show that magnetic nanotubes may be exploited to treat neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease because they can be used as a delivery vehicle for nerve growth factor. Light weight and compact EEG, EOG and EMG textile based monitoring system is capable of monitoring real time epileptic patients and patients with neurological and movement disorders using the Internet and cellular network. Physicians could be able to monitor these signals in real-time using portable computers, Wi-Fi, GSM or cell phones and will give early warning signal if these signals cross a pre-determined threshold level. Selected movies illustrating the applications of nanodevices and systems to patients will be shown at the talk.
Bio: Vijay K. Varadan serves as the Twenty-First Century Endowed Chair in Nano-and Bio-Technology and Medicine, and Distinguished Professor of Electrical Engineering and Distinguished Professor of Biomedical Engineering (College of Engineering) and Neurosurgery (College of Medicine) at University of Arkansas. He is also a Professor of Neurosurgery at the Pennsylvania State University College of Medicine. He joined University of Arkansas in January 2005 after serving on the faculty of Cornell University, Ohio State University and Pennsylvania State University for the past 39 years. At Pennsylvania State University he was Distinguished Alumni Professor and Distinguished Professor of Engineering Science and Electrical Engineering. He was the Director of the University of Arkansas High Density Electronic Center from 2005 till 2010. He is at present the Director of the Center of Excellence for Nano-, Micro-, and Neuro-Electronics, Sensors and Systems and the Director of the NSF Center for Wireless Nanosensors and Systems (WiNS). He is the President of Global Institute of Nanotechnology in Engineering and Medicine (GINTEM). The purpose of this Institute is to create a global effort to solve current and future medical concerns using advanced nanotechnologies by developing Research Hospitals at selected overseas countries.
He has concentrated on the design and development of various electronic, acoustic and structural composites, smart materials, structures, and devices including sensors, transducers, Microelectromechanical Systems (MEMS), synthesis and large scale fabrication of carbon nanotubes, NanoElectroMechanical Systems (NEMS), microwave, acoustic and ultrasonic wave absorbers and filters. He has developed neurostimulator, wireless microsensors and systems for sensing and control of Parkinson’s disease, epilepsy, glucose in the blood and Alzheimer’s disease. He is also developing both silicon and organic based wireless sensor systems with RFID for human gait analysis and sleep disorders and various neurological disorders. He is a founder and the Editor-in-Chief of the Journal of Smart Materials and Structures. He is the Editor-in-Chief of the Journal of Nanotechnology in Engineering and Medicine. He is an Associate Editor of the Journal of Microlithography, Microfabrication and Microsystem. He serves on the editorial board of International Journal of Computational Methods and Journal of Nanotechnology and Nanomedicine Research. He has published more than 500 journal papers and 15 books. He graduated 55 Ph. D, 53 MS and 2 M. Eng students; in University of Arkansas and 2 M.D fellows in Neurosurgery. He has 15 patents pertinent to conducting polymers, smart structures, smart antennas, phase shifters, carbon nanotubes, and implantable device for Parkinson’s patients, MEMS accelerometers, pressure sensors and gyroscopes. He is a fellow of SPIE, ASME, Institute of Physics, Acoustical Society of America.